If the Colts win the Super Bowl this season, I don't think anyone will complain about the 14-2 regular season record.
Football is a business, and you have to protect your investment. Indy clinched the #1 seed and home field throughout, so therefore pull your prized possessions and get ready for the playoffs. Welker's injury today should have a lot of Colts or Saints fans saying to themselves "I'm glad that wasn't Manning or Brees."
The only people I feel sorry for in this situation are fans who could be like me. Going to a game would require a lot of budgeting and if I had the opportunity to see my favorite team late in the year, got there and watched the #1s play two series then I would want a refund as well.